Idiopathic PEV is usually isolated and generally have a good prognosis, their relationship with chromosomal anomalies is limited, and familial cases have been reported ( 5). There may be accompanying anomalies or it can be seen as isolated. Early amniocentesis is one of the iatrogenic reasons that may lead to this ( 6). Positional PEV is mostly associated with intrauterine factors limiting fetal movements, such as oligohydramnios, twin pregnancy and uterine anomalies. Despite advances in molecular gene studies, a major causative gene has not been identified and clinical features of even familial cases show heterogeneity ( 5). It has been associated with some aneuploidies, deletion syndromes, sex chromosome abnormalities, neuromuscular disorders, microdeletion and duplications. Syndromic cases tend to be more complex, and their association with other congenital malformations and/or chromosomal and genetic anomalies is common.
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